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Onuma et al. (2010) analyzed the GCKR SNP rs780094 in 488 Japanese patients with type 2 diabetes and 398 controls and found association between a reduced risk of T2DM and the A allele (odds ratio' 0.711; p = 4.2 x 10(-4)). A metaanalysis with 2 previous association studies (Sparso et al.' 2008 Vaughn WA installment loans and Horikawa et al.' 2008) confirmed the association of rs780094 with T2D susceptibility. In the general Japanese population' individuals with the A/A genotype had lower levels of fasting plasma glucose (see 613463)' fasting plasma insulin' and HOMA-IR than those with the G/G genotype (p = 0.008' 0.008' and 0.002' respectively); conversely' those with the A/A genotype had higher triglyceride levels than those with the G/G genotype (p = 0.028). "